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KMID : 1130920140180040159
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Journal of Korean Foot and Ankle Society
2014 Volume.18 No. 4 p.159 ~ p.164
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Effect of Antiplatelets in Diabetic Peripheral Vasculopathy: Comparison by Ankle-Brachial Index and Peak Wave Velocity
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Park Se-Jin
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Abstract
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Purpose: The purpose of this study is to confirm the effect of antiplatelet drugs in diabetic peripheral vasculopathy in diabetic foot patients.
Materials and Methods: We designed a retrospective study in diabetic foot patients with diabetic peripheral vasculopathy. From October 2007 to December 2013, 278 cases in 139 patients who took antiplatelet drugs over at least a six-month period were included in this study. We categorized these patients according to the type of drug used. The efficacy of antiplatelet drugs was evaluated using anklebrachial index (ABI) and pulse wave velocity (PWV).
Results: Only the aspirin group showed a statistically significant increase of ABI after antiplatelet therapy (1.10±0.12 to 1.12±0.11). In addition, only the cilostazol group showed a statistically significant decrease of PWV after antiplatelet therapy (1,701.20±396.56 to 1,627.42±324.98).
Conclusion: Aspirin and cilostazol may be used in treatment of diabetic peripheral vasculopathy, whereas dual antiplatelet therapy with
aspirin and clopidogrel has no specific benefits in diabetic peripheral vasculopathy.
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KEYWORD
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Diabetes, Diabetic angiopathy, Platelet aggregation inhibitors
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